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The use of AAFs and rice hydrolysates for the prevention of atopic disease has not been studied. Soy formulas, on the other hand, have a long history of use for atopic disease in infants. In a Cochrane review based on 5 RCTs or quasi-RCTs, the authors concluded that feeding with soy formula should not be recommended for the prevention of atopy in infants at high risk of developing allergy [38].