Читать книгу Current Perspectives in Kidney Diseases - Группа авторов - Страница 14

Diverse studies showed the association between serum levels of specific mediators and a worse outcome in septic patients. Soluble CD40-ligand, Fas-ligand and angiopoietin-2 are middle molecules involved in inflammation, coagulation and apoptotic cell damage that were found to be significantly increased in septic critically ill patients with a worse outcome [27]. In recent years, sepsis research also focused on the alterations of peripheral blood cells: it has been shown that a decreased expression of HLA-DR on monocytes is an indicator of immune paralysis and increased death risk [28]. Similarly, the variation of CD56+ Natural killer T cell count, the increase of CD4+CD25+Foxp3+ T regulatory cells, the decreased number of CD8+ T memory cells and the increased percentage of CD34+CD133+KDR+ endothelial progenitor cells in the peripheral blood have been associated with tissue injury and an increased mortality risk [28].