Читать книгу Vitamin D in Clinical Medicine - Группа авторов - Страница 40

Vitamin D-binding protein (DBP) is the main transporter of vitamin D metabolites, initially described as a “group-specific component” (Gc-globulin). It is a multifunctional plasma protein, and besides its function in vitamin D metabolism, it also plays a major role in the clearance of G-actin monomers from plasma. DBP is a highly polymorphic protein, with a pattern of distribution very characteristic in the different ethnic groups, and its variants can present different affinities for vitamin D metabolites. Most of the 25-hydroxyvitamin D and its active form 1,25-dihydroxyvitamin D circulate bound to DBP (85–90%), and only less than 1% are free in the blood. DBP is produced mainly in the liver and can be influenced by many conditions, such as estrogen status, smoking, and malnutrition, which can have an effect on total vitamin D measurements. Recently, DBP has returned to the spotlight due to the discussion about its role in vitamin D physiology, which will be discussed in this chapter.

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