Читать книгу Vitamin D in Clinical Medicine - Группа авторов - Страница 44

Actin is an important cytoskeletal protein, highly conserved in eukaryotic cells. Two main forms of the protein are described, a monomeric globular form (G-actin) and a linear polymeric form called F-actin. Once in the extracellular compartment, actin polymerizes in the filamentary form [2]. The polymer may cause coagulation cascade activation, vascular obstruction, and cellular dysfunction. Actin is released by tissue injury and cell death, and DBP is able to bind to it with high affinity and to prevent filament formation [18]. In conjunction with gelsolin, another serum protein, DBP forms an actin scavenger system. It is able to rapidly sequester free actin from circulation, and the major DBP polymorphisms have equal binding affinity. It is possible that the molar excess of the protein is related to this function [2].