Читать книгу Vitamin D in Clinical Medicine - Группа авторов - Страница 45

All the members of the albumin superfamily of binding proteins are able to transport free fatty acids (FFA). ALB has several low- and high-affinity binding sites for FFA, while DBP has a single high-affinity binding site. ALB is also much more abundant in the plasma, which results in DBP having only a contributory role. The binding of unsaturated FFA reduces DBP affinity for vitamin D metabolites, but this effect is not observed for saturated FFA [17]. These variations are a result of the specific conformational changes induced for each FFA in DBP [2].