Читать книгу Vitamin D in Clinical Medicine - Группа авторов - Страница 47

Chemotaxis is an important process of neutrophil recruitment during inflammation. DBP has no intrinsic chemotactic effect; however, when bound to complement component 5a (C5a), it enhances C5a-mediated neutrophil and macrophage chemotaxis [17]. The action requires binding to cell surface receptor, which is mediated by the residues 130–149 in the protein [12]. Interestingly, binding to vitamin D metabolites (25[OH]D or 1,25[OH]₂D) reduces DBP chemotactic action due to binding site competition [2]. The 3 major polymorphisms (GC1F, GC1S, and GC2) have comparable chemotactic activity.