Читать книгу Vitamin D in Clinical Medicine - Группа авторов - Страница 46

DBP can be deglycosylated by T- and B-cell glycosidases and act as a macrophage activation factor (MAF), which is called DBP-MAF [17]. This activity was discovered when mouse peritoneal cells were stimulated with lysophosphatidylcholine, and it resulted in an increase in phagocytic activity [20]. Analysis revealed that this increase was associated with the deglycosylation of DBP by β-galactosidase and sialidase of the B and T cells, resulting in DBP-MAF. The different isoforms of DBP show variable susceptibility to deglycosylation. This feature could explain the association of the isoforms with diseases like chronic obstructive pulmonary disease, bronchiectasis, and tuberculosis [17].