Читать книгу Hyperandrogenism in Women - Группа авторов - Страница 35

Androgens exert a relevant role in determining body weight and composition, as confirmed by preclinical and clinical studies. In animal models and cell cultures, androgens have been shown to inhibit adipogenic lineage and lipid storage, while favouring muscle cell hypertrophy. In clinical studies in men, low androgens have been associated with increased FM and reduced FFM, both corrected after T replacement therapy; high androgen levels lead to increase FFM and reduce FM. Differences are described depending on sex and the type of adipose tissue (VAT or SAT).