Читать книгу Sarcopenia - Группа авторов - Страница 81

Multiple pathways lead to age‐related muscle loss, which include poor nutrition, physical inactivity, oxidative damage to mitochondrial energy metabolism, upregulation of inflammatory cytokines, hormone resistance syndromes, protein anabolic failure, neurodegeneration, and changes in muscle fiber structure and the neuromuscular junction. Sarcopenia in turn leads to reduction in VO2 peak, reduced physical activity, mobility limitations, and consequent downstream adverse outcomes such as falls and fractures, disability and dependency, poor quality of life, use of hospital services, as well as mortality, contributing to a downward spiral of decline.

Strategies for early detection and intervention would be of public health and clinical importance.