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Alpha2‐adrenergic antagonists

Оглавление

 Atipamezole (Antisedan):Used off‐label for reversal of xylazine, other alpha2‐adrenergic antagonists, and potentially amitraz.Dose: 0.1 mg/kg slow IV.

 Tolazoline (Tolazine):Used primarily to reverse xylazine. The effects may be partial and transient.Dose: 0.5–2 mg/kg IM or very slow IV; labeled dose is 4 mg/kg slow IV.

 Yohimbine (Yoban):Used off‐label to reverse the effects of xylazine, other alpha2‐adrenergic agonists, and potentially amitraz.The half‐life is short (1.5–2 h) and the drug will likely need to be repeated if used to reverse longer‐acting agonists. Yohimbine has more side‐effects including CNS excitation, tremors, and hypersalivation.Dose: 0.05–0.2 mg/kg IM or very slow IV.

Blackwell's Five-Minute Veterinary Consult Clinical Companion

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