Читать книгу Diagnostics and Therapy in Veterinary Dermatology - Группа авторов - Страница 23

Immune complexes are antigens bound to their antibodies. When excessive amounts of antigen are present in the body, more complexes than can be cleared efficiently by the body are formed. These complexes precipitate in tissue in large amounts and cause severe inflammation. The antigen–antibody complexes may remain at the initial site of attack or move through the bloodstream and lodge in distant locations such as capillaries or renal glomeruli. Once in the tissue, they trigger the accumulation of neutrophils, which release oxidants, inflammatory mediators, and enzymes that trigger additional inflammation and tissue damage. This type of hypersensitivity reaction is seen in many tick‐borne diseases and leishmaniasis, as well as autoimmune diseases such as systemic lupus erythematosus and vasculitis.