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A drug concentration in a whole blood was measured as 1 mg/L. If the plasma was then separated from the whole blood, then the 1 mg of the drug that was present in the whole blood will now be present in the plasma provided that the drug does not bind to the RBCs (red blood cells).

In a typical healthy male, plasma represents ~55% of the total blood volume. This will mean that the 1 mg of the drug will now be present in 0.55 L of the plasma instead of 1 L of the whole blood.

This represents a plasma concentration of 1.8 mg/L, which is higher than the 1 mg/L – the concentration measured in the whole blood sample.