Читать книгу Biopharmaceutics - Группа авторов - Страница 29

The drug is removed out of the body through metabolism and direct elimination via excretion. The process is often referred to as clearance in pharmacokinetics. The metabolism involves structural changes by biotransformation of the drug into different chemical entities, usually referred to as metabolites which can still be pharmacologically active (produce a therapeutic effect or are responsible for adverse reactions). These metabolites along with the unmetabolized drug are then subjected to excretion via the kidneys.

Figure 2.6 A typical drug distribution into the body following an intravenous dose.