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The volume of distribution (V) of a drug is a pharmacokinetic term that represents the hypothetical volume of total body tissues where a drug is distributed following administration. It is denoted in appropriate units of volume, usually litres (L) or litres per kilogram body weight (L/kg). Water represents most of the body weight, with total body water estimated approximately 42 L in a 70 kg healthy male that accounts for the 60% of the total body weight (Box 2.3). The total body water is represented by the blood volume (~5 L), the interstitial fluids (~11 L) and the intracellular fluids (~28 L).