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Box 2.5 The elimination rate constant, k and the elimination half‐life (t½)
ОглавлениеIf the k = 0.1 h–l it will mean that ~10% of the drug left in the body will be eliminated in the next hour.
| Time | Amount eliminated (mg) | Amount in body (mg) |
|---|---|---|
| 0 | 0 | 100 |
| 1 | 10 | 90 |
| 2 | 9 | 81 |
| 3 | 8.1 | 72.9 |
| 4 | 7.3 | 65.6 |
| 5 | 6.6 | 59.0 |
| 6 | 5.9 | 53.1 |
| 7 | 5.3 | 47.8 |
The amount of the drug left in the body at seven hours is reduced to half of the original amount at time zero, correlating to the drug's half‐life, i.e. t½ = 7 h.
Figure 2.9 The relationship of total body clearance, renal and non‐renal clearance and kidney function.
