Читать книгу Biopharmaceutics - Группа авторов - Страница 69

Drug solubility in a range of solvents is of interest for both the prediction of biopharmaceutics parameters and also to aid in the formulation strategy. Drug solubility in a range of organic solvents can facilitate polymorph identification and process optimisation. For compounds that show poor aqueous solubility, additional solubility screening is performed with a range of solubilising vehicles to guide the formulation design and associated risk assessment.