Читать книгу Biopharmaceutics - Группа авторов - Страница 73

The gastrointestinal tract is maintained in equilibrium via secretions and its composition has been well characterised in the fasted state. In the fed state the secretions change and in addition there is digestion of the consumed food. Thus it is not only the effect of endogenous surfactants but also ingested nutrients and digestion products that can affect drug solubility. For example, when short‐chain fatty acids are ingested, they are hydrolysed and then incorporated into the bile micelles to further solubilise certain drugs. Work has been conducted on simulated media that include lipolysis products within the media [15]. Oleic acid and monoolein are often used within the media to replicate the lipolysis products [16].