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The lipophilicity of a compound is described in terms of a partition coefficient, log P, which is defined as the ratio of the concentration of the unionised compound, at equilibrium, between organic and aqueous phases. Since it is virtually impossible to determine log P in a realistic biological medium, octanol has been widely adopted as a model of the lipid phase. Generally, drug compounds with log P values between 1 and 3 show good bioavailability.