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Predictors of muscle hypertrophy after exercise

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There is some controversy about whether there are significant gender differences in the functional or hypertrophic response to resistance training in the elderly. Some studies have found women to have smaller gains in muscle strength and power or hypertrophic response to training, whereas others have found no differences or even greater gains in women. It is likely that differences in training regimens (particularly related to intensity) and measurement techniques used to assess muscle mass, cross‐sectional area or volume may explain some of these discrepant results. Malnutrition, impaired protein synthesis rates, inflammatory cytokines, and depression are other factors that have been identified as detrimental to robust anabolic and functional adaptations to resistance training in some studies, and the role of genetic and epigenetic influences is still under investigation.91

Pathy's Principles and Practice of Geriatric Medicine

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