Читать книгу Ridley's The Vulva - Группа авторов - Страница 189

These cause a significant inflammatory reaction and need to be applied much less frequently than in extragenital sites. Patients will often tolerate only once or twice weekly treatment for the vulva. Silver sulphadiazine cream can be used as a soothing rescue if the soreness is particularly severe. Flu‐like symptoms are reported by some patients. Cases are reported where the development of another dermatosis, such as vulval pemphigus, has been linked to the use of imiquimod [17]. Lichen sclerosus and lichen planus have been described after its use in males [18]. It needs to be used with care in patients with a pre‐existing dermatosis, as more severe reactions can occur. One patient with Behcet’s disease using imiquimod to treat genital warts developed very large ulceration with its use [19].

The other adverse effect is a change in pigmentation with imiquimod. Vitiligo‐like hypopigmentation can occur which may be long‐lasting [20].