Читать книгу Ridley's The Vulva - Группа авторов - Страница 193

PDT relies on the interaction between a photosensitiser, oxygen, light, and the tissue affected [27]. The photosensitisers generally used are aminolevulinic acid (5‐ALA) or methyl aminolevulinate (MAL). These are applied to the lesion and reactive oxygen species are generated, which when activated by blue or red light cause cell death. It can be used systemically, but topical PDT is the most widely used. Only the abnormal cells which take up the photosensitiser are damaged so that the surrounding skin is unaffected, therefore giving good cosmetic results. It has been used to treat lichen sclerosus (LS), lichen planus (LP), HSIL, and extra‐mammary Paget’s disease.