Читать книгу Ridley's The Vulva - Группа авторов - Страница 192

Ultraviolet radiation (UVR) has been used to treat skin disease since ancient times. It is mainly used to treat psoriasis, but several other dermatoses will respond [25]. The wavelengths used in treatment are ultraviolet A (UVA) (320–380 nm) and ultraviolet B (UVB) (280–320 nm). Exposure to UVR induces direct DNA damage and a shift of the immune response to Th2.

In phototherapy with photochemotherapy (PUVA; psoralen and UVA), psoralen is either taken orally or applied topically to enhance the effect of the UVA. This treatment causes the most DNA damage and has carcinogenic potential. Its use has been reported in small studies in genital dermatoses [26]. However, it is limited in vulval disease as it difficult to expose the genital area to light in isolation, and there are concerns about the carcinogenic risk.