Читать книгу Magnetic Resonance Microscopy - Группа авторов - Страница 23

In situations in which microscopy is desired of objects that themselves have small dimensions, then there is an MR sensitivity advantage when using micro detectors. The challenge of sample handling at these dimensions, often achieved by microfluidic systems, can be turned into a feature when one considers the library of lab-on-a-chip (LOC) technologies already available, offering additional degrees of freedom in terms of sample management and interaction. Integration of NMR and microfluidics has continued to advance, starting from the earliest microcoil reports [43,44] to recent efforts taking advantage of LOC principles to enable microfluidic-based perfusion [35,45–49], electrochemistry [50], and hyperpolarization [51–53]. As discussed extensively in this chapter, micro-NMR coupled with MR microscopy is established and continues to evolve, with one branch of this evolution now extending toward fully exploring the augmented micro-MR system to further enhance the applicability of MR microscopy.