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To identify differentially expressed EV-associated miRNAs, we performed RNA-Seq on a size-selected EV-associated small RNA library for three doses of CCl₄, namely 0, 7, and 70 mg/kg. We obtained forty-five differentially expressed EV-associated miRNAs, including forty-five upregulated genes and no downregulated genes, between the corn oil and 70 mg/kg CCl₄ samples, while only one differentially expressed (upregulated) EV-associated was identified between the corn oil and 7 mg/kg CCl₄ samples (see Figure 3.10; also Ono et al. 2020).

Figure 3.10 Differentially expressed EV-associated miRNAs. Individual normalized counts for four differentially expressed EV-associated miRNAs are shown. **P < 0.001, *P < 0.01 vs. control.