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Genomic and Epigenomic Biomarkers of Toxicology and Disease
Читать книгу Genomic and Epigenomic Biomarkers of Toxicology and Disease - Группа авторов - Страница 1
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Вернуться на страницу книги Genomic and Epigenomic Biomarkers of Toxicology and Disease
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Страница 1
Genomic and Epigenomic Biomarkers of Toxicology and Disease Clinical and Therapeutic Actions
Страница 3
Contents
List of Illustrations
List of Tables
Guide
Pages
Dedication
Preface
Acknowledgements
List of Contributors
1 Genomic and Epigenomic Biomarkers for Predictive Toxicity and Disease
Toxicity Testing in the Twenty-First Century
Biomarkers
Genomic Biomarkers
Epigenomic Biomarkers
MicroRNAs
Circular RNAs
The Need for a Book on Genomic and Epigenomic Biomarkers for Predictive Toxicity and Disease
References
2 MicroRNAs as Non-invasive Biomarkers of Toxicity and Chemical Hazard Genomic and Epigenomic Biomarkers of Toxicology and Disease
Introduction
Mechanisms that Contribute to Extracellular miRNA Release
Packaging into Vesicles and Mechanisms of Release
Biological Interpretations Due to Mechanisms of Release
MicroRNAs as Bioindicators of Toxicity and Disease
Application
Challenges and Future Focus
Conclusions
Acknowledgements
References
3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity
Introduction
The Classification of Extracellular Vesicles (EVs)
Components of Exosomes (EVs) RNAs
Proteins
Physiological and Cellular Functions of EVs
Cancer Biomarkers
Toxicology Biomarkers
Isolation and Characterization of EVs from Mouse Blood
Carbon Tetrachloride (CCl
4
) Administration and Histology
Identification of Differentially Expressed miRNAs by RNA-Seq
Conclusion
Acknowledgments
Competing Interests
Funding
References
4 Circulating miRNAs as Biomarkers of Toxic Heavy Metal Exposure
Metals and the Focus of This Chapter
Exposure to Metals
Biomarkers
Biomarkers of Heavy Metal Exposure
miRNA Biogenesis
Circulating miRNAs as Biomarkers for Disease
Circulating miRNAs Associated with Arsenic Exposure
Circulating miRNAs Associated with Lead Exposure
Circulating miRNAs Associated with Mercury Exposure
Circulating miRNAs Associated with Cadmium Exposure
Circulating miRNAs Associated with Chromium Exposure
Circulating miRNAs Associated with Mixed Metals Exposure
Summary of Potential Circulating miRNA Biomarkers for Heavy Metals
Future Avenues of Research
Techniques and Challenges for Identifying Circulating miRNAs
Acknowledgement
References
5 MicroRNA Biomarkers of Malignant Mesothelioma
Methods for Detecting the Expression of miRNAs
Early Screening for Malignant Mesothelioma
Diagnosis of Malignant Mesothelioma
Differential Expression of miRNAs in Cancer Tissues
Differential Expression of MicroRNAs in Serum and Plasma
Differential Expression of miRNAs in Pleural Effusion
MicroRNAs Associated with Malignant Mesothelioma Tissue Subtypes
Differential Diagnosis
MicroRNAs Related to the Occurrence and Development of Mesothelioma
MicroRNAs Related to Cell Cycle Regulation
MicroRNAs Related to Proliferation and Clone Formation
MicroRNAs Associated with Migration and Invasion
Apoptosis-related miRNAs
Inhibition of miRNAs Associated with Explant Tumor
Exosomal miRNA as a Target for Malignant Mesothelioma
MicroRNAs Related to Prognosis of Malignant Mesothelioma
References
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