Читать книгу Genomic and Epigenomic Biomarkers of Toxicology and Disease - Группа авторов - Страница 78

Abnormal cell proliferation is an important feature of tumors, and miRNA can regulate genes related to cell proliferation. Therefore the targeted regulation of miRNAs involved in cell proliferation may be helpful to the treatment of MM, and related studies have been reported. Some studies have transfected miR-31 analogues into MM cells and induced miR-31 precursor expression, and found that cell proliferation and the clone formation ability were significantly weakened. Similarly, there have been studies on the decrease of intracellular target protein expression after the transfection of miR-16 analogue and miR-145 activator into tumor cell lines, and the decrease of target protein expression is positively correlated with miRNA transfection concentration, while cell proliferation and clone formation are inhibited. However, the proliferation of normal mesothelial cells transfected with related miRNAs was not affected (Cioce et al. 2014; Reid et al. 2013). In addition, it has been reported that butterfly element (EphA2) inhibits the growth of MM cells by promoting the expression of let-7a1 and by inhibiting the proto-oncogene RAS. When MM cells are transfected with the precursor of miRNAlet-7, the expression of proto-oncogene RAS is inhibited, and cell proliferation is also inhibited (Khodayari et al. 2011).