Читать книгу Genomic and Epigenomic Biomarkers of Toxicology and Disease - Группа авторов - Страница 80

In the process of tumor formation and malignant transformation, tumor cells escape the monitoring system by avoiding apoptosis and survive in the microenvironment of tumor growth. Studies have found that miRNA may play a role in inducing apoptosis. The expression levels of miR-1(Kirschner et al. 2012) and miR-34b/c(Kubo et al. 2011) decreased in MM cell lines. After transfection of miR-1 and adenovirus carrying miR-34b/c into tumor cell lines, the number of early and late apoptosis of tumor cells increased significantly. It indicated that miR-1 and miR-34b/c could promote the apoptosis of MM cell.