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Studies have shown that the expression of some miRNAs in cancer tissues or body fluids of patients with MM is dysregulated and affects the expression of target genes, which may play an important role in the occurrence and development of malignant mesothelioma. In addition, some differentially expressed miRNAs have a certain specificity, which can distinguish MM from lung adenocarcinoma and other tumors. In consequence, these miRNAs can be used as biomarkers of MM for clinical diagnosis and differential diagnosis (Kirschner et al. 2012).