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This work was supported in part by Research on the Regulatory Science of Pharmaceuticals and Medical Devices (20mk0101163j0202), Research on the Development of New Drugs (20ak0101093j003) from the Japan Agency for Medical Research and Development, the Health Sciences Research Grants from the Ministry of Health, Labor, and Welfare, Japan, (H30-KAGAKU-IPPAN-002, 21KD1001), and JSPS KAKENHI (18K19315) to R.O.; Grant-in-Aid from the Research Program on Hepatitis from Japan Agency for Medical Research and Development (AMED: 16fk0310512h0005, 17fk0310101h0001 and 18fk0310101h0002) and Grants-in -Aid from a Project for Cancer research and Therapeutic Evolution (P-CREATE) to T. O.; JSPS KAKENHI (18K07053) to Y. H.