Читать книгу Sustainable Nanotechnology - Группа авторов - Страница 50

The study has shown that the membrane diffusion of NMs is deviated based on its surface structure design. Yet, the type of surface of the NMs and their relationship with membrane diffusion are far from being broadly understood [36, 37]. Classically, interactions between NMs and the tissues of living things are driven by the chemical functionalities on the surface in addition to their shape and size. The importance of the surface can also be enlightened from a well‐known phenomenon of naturally occurring peptides that show the inability to perform their fate of getting diffused into the cell membrane if they remain in random coil configuration rather than specific helical structure [36]. Different shapes, viz., fiber, spheres, tubes, ring, and planes, have been assessed to achieve their potential characteristics, including their adverse effects. Nickel NPs used in electronic application while testing toxicity based on size demonstrated that the change in configuration has more toxicity rather than the size [37]. The data shows that endocytosis of globular particle is quicker when compared to cylinder‐shaped particles in nanoscale [38]; further toxicity of globular NPs is based on whether their configuration is homogenous or heterogeneous [39], and if they are other than spherical, then they will quickly show movement in systemic circulation, with possible biological consequences [40].