Читать книгу Plant Nucleotide Metabolism - Hiroshi Ashihara - Страница 57

FGAM synthesis from FGAR and glutamine is catalysed by formylglycinamide ribonucleotide amidotransferase (FGAMS, EC 6.3.5.3), in a reaction that requires ATP (step 4 in Figure 4.1, Reaction 4).

The pur4 gene encodes the N-terminal portion of the FGAMS protein which contains targeting sequences of the FGAMS protein of A. thaliana suggesting that this enzyme is located in mitochondria as well as chloroplasts (Berthome et al. 2008). It has also been postulated that the FGAMS-catalysed step is crucial for plant reproduction, in particular male gametophyte development, but it probably also occurs in the sporophytic tissues sustaining pollen and embryo sac developments (Berthome et al. 2008).