Читать книгу Plant Nucleotide Metabolism - Hiroshi Ashihara - Страница 61

Fumarate is released from SAICAR in the formation of aminoimidazole carboxamide ribonucleotide (AICAR) (step 8, Figure 4.1, Reaction 8). The reaction is catalysed by adenylosuccinate lyase (ASL, EC 4.3.2.2). This enzyme also catalyses the cleavage of adenylosuccinate leading to the production of AMP and fumarate (step 12). The encoding pur8/12 gene has been cloned from A. thaliana.