Читать книгу Principles of Virology - Jane Flint, S. Jane Flint - Страница 251

Influenza virus is among the few RNA-containing viruses with genomes that are replicated in the cell nucleus. The influenza virus genome, which consists of eight segments, is uncoated in the cytoplasm. After vRNPs separate from M1 and are released into the cytosol, they are imported rapidly into the nucleus (Fig. 5.26A). Import depends on the presence of a nuclear localization signal in the NP protein, a component of vRNP: naked viral RNA does not dock onto the nuclear pore complex, nor does it enter the nucleus.