Читать книгу Principles of Virology - Jane Flint, S. Jane Flint - Страница 259

Bullough PA, Hughson FM, Skehel JJ, Wiley DC. 1994. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371:37–43.

Wilson IA, Skehel JJ, Wiley DC. 1981. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 289: 366–373.

These two seminal papers were the first to report the structure of a viral fusion protein, influenza HA. These studies established the foundation of models for the conformational changes occurring in viral proteins during fusion.

Butan C, Filman DJ, Hogle JM. 2014. Cryo-electron microscopy reconstruction shows poliovirus 135S particles poised for membrane interaction and RNA release. J Virol 88:1758–1770.

This study shows the structural changes occurring in the poliovirus capsid shell during entry.

Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR. 2011. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature 477:340–343.

This paper first identified the receptor for ebolavirus.

Conley MJ, McElwee M, Azmi L, Gabrielsen M, Byron O, Goodfellow IG, Bhella D. 2019. Calicivirus VP2 forms a portal-like assembly following receptor engagement. Nature 565:377–381.

This paper shows the formation of a pore in the capsid shell of caliciviruses that would allow the delivery of the (+) strand RNA genome to the cytoplasm.

Harutyunyan S, Kumar M, Sedivy A, Subirats X, Kowalski H, Köhler G, Blaas D. 2013. Viral uncoating is directional: exit of the genomic RNA in a common cold virus starts with the poly-(A) tail at the 3′-end. PloS Pathog 9:e1003270.

This study challenged the idea that the viral RNA 5′ end is first to exit the capsid during entry of all picornaviruses.

Kane M, Rebensburg SV, Takata MA, Zang TM, Tamashita M, Kvaratskhelia M, Bieniasz PD. 2018. Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2. Elife 7:e35738.

This paper examines the intertwined role of nucleoporins in HIV-1 nuclear import.

Liu J, Yu C, Gui JF, Pang DW, Zhang QY. 2018. Real-time dissecting the entry and intracellular dynamics of single reovirus particle. Front Microbiol 9:2797.

This paper uses microscopy techniques to track the entry of individual reovirus particles into cells.

Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S,Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE Jr, Aman MJ, Lai JR, Chandran K. 2016. A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses. Science 354:350–354.

This study relies on the unique understanding of Ebolavirus entry to generate novel antibodies that inhibit entry by being delivered to the appropriate subcellular compartment.