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Sometimes, quite large chronic forebrain lesions will be present but clinically silent (Figure 2.5), whereas smaller but acute lesions can often have clinical expression.

Figure 2.5 Large regions of the forebrain of large domestic animals can be regarded as “clinically silent” because when affected by disease processes there may be minimal or no associated clinical signs. Such was the case with a yearling horse whose brain is shown here in section with a defect in the right parietal cerebral cortex that likely resulted from a vascular infarct. At the acute stage of disease, this patient, as a neonate, did demonstrate mild obtundation and wandering in wide circles to the right but made a full clinical recovery within a few days.