Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 154

The corrosive action of zinc phosphide accounts for the early, acute and generally haemorrhagic emetic effect on the gastric mucosa. The systemic toxicity of zinc phosphide is caused by phosphine. Postulated mechanisms of action of phosphine include inhibition of cytochrome C oxidase with mitochondrial dysfunction and interruption of cellular respiration, inhibition of serum acetyl cholinesterase activity resulting in cholinergic overdrive and formation of reactive oxygen species (ROS) with resultant oxidative stress, damage to cell lipids, proteins and nucleic acids and cell death (Proudfoot, 2009).