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Prognosis

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The mortality rate in dogs is reported to range from 59% to 70% and is thought to be even higher in cats. However, prognosis has been reported to be favourable in dogs and cats treated within 8 and 3 h following ingestion, respectively (Thrall et al., 2006).

Table 4.2. Fomepizole and ethanol dosage in the treatment of ethylene glycol toxicity.

MedicationSpeciesDosage
FomepizoleDog20 mg/kg IV initially as a loading dose, followed by 15 mg/kg IV at 12 and 24 h, and 5 mg/kg IV at 36 h
FomepizoleCat125 mg/kg IV initially, followed by 31.25 mg/kg IV 12, 24 and 36 h after the initial bolus
20% ethanolDog5.5 ml/kg of a 20% solution IV every 4 h for five treatments, then every 6 h for four additional treatments; or 22 ml/kg IV of a 5% solution every 4 h for six treatments, then every 6 h for four treatments; or a constant rate IV infusion of 5% solution at 5.5 ml/kg/h
20% ethanolCat5 ml/kg of a 20% solution IV every 6 h for five treatments, then every 8 h for four additional treatments
Canine and Feline Epilepsy

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