Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 166

Ethylene glycol is biotransformed to glycolic acid, which is metabolized to formic acid, oxalic acid and oxalate. These metabolites are highly toxic and result in severe metabolic acidosis and acute renal failure. The oxalate combines with calcium to form oxalate crystals in renal tubules (especially proximal), urine and within the lumen or perivascular space of cerebral capillaries (Dial et al., 1994a).

Hypocalcaemia secondary to calcium oxalate deposition may contribute to CNS signs, although the concurrent metabolic acidosis shifts calcium to the ionized active state, reducing the chances of hypocalcaemia-associated clinical signs. Acidosis may also contribute to cerebral damage.