Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 45

While seizure initiation is driven at least in part by the burst-firing properties of the individual neurons, the evolution and spread of the seizures also requires amplification and synchronization among neurons within susceptible networks. Seizure amplification occurs through the action of recurrent excitatory collaterals that form feedback loops, returning excitatory synaptic activity to the neurons within the seizure onset zone (Rutecki et al., 1989; Coulter and DeLorenzo, 1999). Seizure spread depends on the propagation and synchronization of the seizure discharge across synapses that separate neurons in the seizure onset zone from ‘normal’ neurons synaptically connected to the seizure onset zone (MacVicar and Dudek, 1980; Miles and Wong, 1983).