Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 56

Once a clinician encounters pharmacoresistant epilepsy, the first question to be asked should be about the possibility of an identifiable, underlying disease process. If seizures persist because the underlying disease has not been identified and treated incorrectly, it is termed pseudoresistance. Conditions mimicking epilepsy (see Chapter 9) need to be also considered; these include cardiac associated syncope, transient vestibular disorders, movement disorders and episodic pain. Sometimes AED treatment can aggravate such mimics (Penning et al., 2009) and so each patient presenting with assumed pharmacoresistant epilepsy needs to be thoroughly investigated with an open mind. One may also encounter failure of AED therapy if owner compliance is poor or pharmacokinetic and -dynamic properties were not considered adequately.