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Martinez J. Hewlett
Basic Virology
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Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
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CHAPTER 1 Introduction – The Impact of Viruses on Our View of Life
THE SCIENCE OF VIROLOGY
The effect of virus infections on the host organism and populations – viral pathogenesis, virulence, and epidemiology
The interaction between viruses and their hosts
The history of virology
Examples of the impact of viral disease on human history
Examples of the evolutionary impact of the virus–host interaction
The origin of viruses
Viruses have a constructive as well as destructive impact on society
Viruses are not the smallest self‐replicating pathogens
QUESTIONS FOR CHAPTER 1
CHAPTER 2 An Outline of Virus Replication and Viral Pathogenesis
VIRUS REPLICATION
Stages of virus replication in the cell
PATHOGENESIS OF VIRAL INFECTION
Stages of virus‐induced pathology
Initial stages of infection – entry of the virus into the host
The incubation period and spread of virus through the host
Multiplication of virus to high levels – occurrence of disease symptoms
Later stages of infection – changes in the cell
The later stages of infection – the immune response
The later stages of infection – virus spread to the next individual
The later stages of infection – fate of the host
QUESTIONS FOR CHAPTER 2
CHAPTER 3 Virus Disease in Populations and Individual Animals
THE NATURE OF VIRUS RESERVOIRS
Some viruses with human reservoirs
Some viruses with vertebrate reservoirs
VIRUSES IN POPULATIONS
Viral epidemiology in small and large populations
Factors affecting the control of viral disease in populations
ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS
A mouse model for studying poxvirus infection and spread
Rabies: where is the virus during its long incubation period?
Herpes simplex virus latency
Murine models
Rabbit models
Guinea pig models
QUESTIONS FOR CHAPTER 3
CHAPTER 4 Patterns of Some Viral Diseases of Humans
THE DYNAMICS OF HUMAN–VIRUS INTERACTIONS
The stable association of viruses with their natural host places specific constraints on the nature of viral disease and mode of persistence
Classification of human disease–causing viruses according to virus–host dynamics
Viral diseases leading to persistence of the virus in the host are generally associated with viruses having long associations with human populations
Viral diseases associated with acute, severe infection are suggestive of zoonoses
PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS
Acute infections followed by virus clearing
Colds and respiratory infections
Influenza
Variola
Infection of an “accidental” target tissue leading to permanent damage despite efficient clearing
Persistent viral infections
Papilloma and polyomavirus infections
Herpesvirus infections and latency
Other complications arising from persistent infections
Viral and subviral diseases with long incubation periods
Rabies
HIV/AIDS
Prion diseases
SOME VIRAL INFECTIONS TARGETING SPECIFIC ORGAN SYSTEMS
Viral infections of nerve tissue
Examples of viral encephalitis with grave prognosis
Rabies
Herpes encephalitis
Viral encephalitis with favorable prognosis for recovery
Viral infections of the liver (viral hepatitis)
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis delta (D)
Hepatitis E
QUESTIONS FOR CHAPTER 4
Problems PART I
Additional Reading for
Part I
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CHAPTER 5 Virus Structure and Classification
THE FEATURES OF A VIRUS
Viral genomes
Viral capsids
Viral envelopes
CLASSIFICATION SCHEMES
The Baltimore scheme of virus classification
Disease‐based classification schemes for viruses
THE VIROSPHERE
THE HUMAN VIROME
QUESTIONS FOR CHAPTER 5
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