Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 51

In the route presented, the key C─N bond is formed by ring‐opening of an epoxide. Draw the structures of the retrosynthetic analysis of an alternative route to atazanavir which forms the same key C─N bond but does not involve an epoxide intermediate. List the pros and cons for both routes and select one route as the preferred route.