Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 65

Bedaquiline is converted to a 1 : 1 salt with fumaric acid in the final step of the manufacturing process. Calculate the overall yield of bedaquiline fumarate (1 : 1) from 4‐bromoaniline. (What percent of the 4‐bromoaniline starting material is lost to waste?)