Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 56

Antineoplastics and Immunosuppressives/Immunosuppressive Medicines

Medicines for Diseases of Joints/Disease‐Modifying Agents Used in Rheumatoid Disorders

An aromatic thioether is often formed by displacement of chloride or bromide by a thiol.

Discussion. The thioether is formed in the final step by displacement of chloride from 5‐chloro‐1‐methyl‐4‐nitroimidazole by 6‐mercaptopurine. 5‐Chloro‐1‐methyl‐4‐nitroimidazole is formed by nitration of 5‐chloro‐1‐methylimidazole. 5‐Chloro‐1‐methylimidazole is formed from N,N′‐dimethyloxamide (Wallach Imidazole Synthesis). The oxamide is formed from diethyl oxalate and methylamine. 6‐Mercaptopurine is formed from hypoxanthine.