Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 55
Extended Discussion
ОглавлениеThe yield in the first one‐pot synthesis of tropinone, described by Robinson in 1917, was just 17%. After a century of process development, the yield for the one‐pot synthesis is now 90%! List the references for the available procedures, the process modification(s) made, and the tropinone yield. Which process modification had the greatest impact on the yield?