Читать книгу Fundamentals of Analytical Toxicology - Robin Whelpton - Страница 32

The measurement of plasma concentrations of drugs given in therapy is useful in assessing adherence and for compounds for which pharmacological effects cannot be assessed easily and for which the margin between adequate dosage and overdosage is small, as discussed in Chapter 20. The availability of a variety of immunoassay and other kits means that many TDM assays can be performed more conveniently by such means than by chromatographic methods. However, chromatographic assays are still important in the case of antiepileptic, antimicrobial, antipsychotic, and immunosuppressant drugs, for amiodarone, where it has proved impossible to produce an antibody that does not cross-react significantly with thyroxine and tri-iodothyronine, and in general where active metabolites need to be measured as well as the parent compound. Examples include carbamazepine/carbamazepine-10,11-epoxide, clozapine/norclozapine, procainamide/N-acetylprocainamide, and amitriptyline/nortriptyline.