Читать книгу Fundamentals of Analytical Toxicology - Robin Whelpton - Страница 70

Analysis of blowfly (Calliphora vicina) and other insect larvae that feed on rotting flesh may facilitate detection of many drugs originally present in human or animal tissues, although quantitative extrapolations are unreliable (Introna et al., 2001; Tracqui et al., 2004; da Silva et al., 2017). Pupae may be preserved for years, but drug and metabolite concentrations in post-feeding and pupating larvae are much lower than in feeding larvae, suggesting that the larvae metabolize and eliminate drugs during development. Metabolism of nordazepam to oxazepam by blowfly larvae has been observed (Pien et al., 2004).