Читать книгу Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations - Sheila Annie Peters - Страница 22

The CL estimated from dose and AUC (Equation 1.10) is the overall clearance of the drug from blood, also called the total clearance. Several clearance pathways could contribute to the total clearance of a drug. Hepatic metabolism, renal, and biliary pathways are some of the clearance routes available for a xenobiotic. The most common route is hepatic metabolism. A drug may utilize one or more clearance pathways depending on its physicochemical properties. The total clearance of a drug is the sum of its hepatic (CL_H ), renal (CL_R ), and biliary (CL_B ) clearances.

(1.23)

CL_organ is the clearance from an eliminating organ, Q_organ is the blood flow rate to that organ, C_ART and C_VEN are the arterial and venous concentrations. (Q_organ × C_ART − Q_organ × C_VEN ) is the rate of elimination from that organ.