Читать книгу Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations - Sheila Annie Peters - Страница 39

Following oral drug administration, some drugs have high hepatic and/or gut extraction due to first pass metabolism. The amount of a metabolite of interest in systemic circulation at any given time is the sum of the amounts from the first pass and from the fraction of parent drug escaping first pass (Figure 1.10).