Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 104

Production of new DnaA in the ATP-bound form is one mechanism for increasing the DnaA-ATP/DnaA-ADP ratio in cells. There are also two mechanisms involved in “recycling” DnaA by encouraging it to exchange a nucleotide, putting it back into the DnaA-ATP form; one involves an exchange catalyzed by acidic phospholipids, and the other involves two sites found in the chromosome called DnaA-reactivating sequences (see Fujimitsu et al., Suggested Reading). The numerous inputs work together to limit the initiation of DNA replication to help keep the number of chromosomes consistent with the requirements for cell division.